Bethel Biocon
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Conjugation Technologies
Random Conjugation
Interchain cysteine conjugation
Site-specific conjugations:
Antibody engineered technologies
Enzyme-mediated
Glycan remodeling…
Linker Design & Synthesis
Noncleavable linkers
Cleavable linkers
pH Responsive
Protease and hydrolase cleavable
Redox-responsive linkers
Emerging linkers….
Payload
Chemotherapy agents
Immune stimulator/suppressor agents
Protac agents
Metabolic disruptor agents
Oligonucleotides
Consultancy
Assess differentiation, risk, and scalability of conjugations
CMC and manufacturability strategy to de-risk development early.
Provide technical due diligence for investors, partners, and internal decision-makers
Independent SME advisory support